Naga Leelaram Majety

Accomplished Senior Post Doctoral Researcher with a robust background in Protein biochemistry and analysis with a proven track record at ETH Zurich and Max-Planck Institute for Biophysical Chemistry. Specializes in protein, antibody and spliceosome purification, demonstrating exceptional analytical skills and a commitment to advancing scientific understanding. Renowned for meticulous research and effective team collaboration.

• Alexander von Humboldt fellowship, 01/01/14, 01/01/17
• Council of Scientific and Industrial Research (CSIR) fellowship, Awarded for five years by the Govt. of India through National Eligibility Test (NET).
• Qualified Graduate Aptitude Test in Engineering (GATE), In 2003 with 95.49 percentile (All India 150th rank).
• Merit certificate, For securing University second rank in Master of Science in Biotechnology.
• University fellowship, For securing University first rank in Master of Science in Biotechnology 1st year.
• Student fellowship, For M.Sc. Biotechnology course (2001-2003) through All India entrance test conducted by Department of Biotechnology (DBT), Govt. of India.
• First rank, In 12th standard, Senior Secondary School.
• Best student award, By Akhila Bharatha Vidyarthi Parishath (ABVP, All India Student Union) for standing first in school in 10th standard, High School.

• Telugu
• English
• Hindi
• German (B1 level)

• Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation, Cole Townsend, Majety N Leelaram, Dmitry E Agafonov, Olexandr Dybkov, Cindy L Will, Karl Bertram, Henning Urlaub, Berthold Kastner, Holger Stark and Reinhard Lührmann, Science, 2020, 370, 6523, (Equal contribution)
• Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation, Bertram Karl, Dmitry E Agafonov, Olexandr Dybkov, David Haselbach, Majety N Leelaram, Cindy L Will, Henning Urlaub, Berthold Kastner, Reinhard Lührmann, Holger Stark, Cell, 2017, 170, 4, 701-713
• Type IA topoisomerase inhibition by clamp closure, Majety N Leelaram, Anuradha G Bhat
• Adwait A Godbole, Rajeshwari S Bhat, Ramanathapuram Manjunath and Valakunja Nagaraja, The FASEB J., 2013, 27, 3030-8,
• Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium, Majety N Leelaram, Shivanand M Hegde, Ramanathapuram Manjunath and Valakunja Nagaraja, FEBS J., 2012, 279, 55-65,
• A new ELISA plate based microtiter well assay for mycobacterial topoisomerase I for the direct screening of enzyme inhibitory monoclonal antibody supernatants, Majety N Leelaram, Nunna Suneetha, Valakunja Nagaraja and Ramanathapuram Manjunath, Journal of Immunological Methods, 2010, 257, 26-32
• Immunological cross-reactivity of mycobacterial topoisomerase I and divergence from other bacteria, Majety N Leelaram, Anuradha G Bhat, Nunna Suneetha, Valakunja Nagaraja and Ramanathapuram Manjunath, Tuberculosis, 2009, 89, 256-262
• Deciphering the distinct role for the metal coordination motif in the catalytic activity of Mycobacterium smegmatis topoisomerase I, Anuradha G Bhat, Majety N Leelaram, Shivanand M Hegde and Valakunja Nagaraja, Journal of Molecular Biology, 2009, 393, 788-802
• Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity, Adwait A Godbole, Majety N Leelaram, Anuradha G Bhat, Paras Jain and Valakunja Nagaraja, Arch Biochem Biophys, 2012, 528, 197-203
• Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage, Wareed Ahmed, Anuradha G Bhat, Majety N Leelaram and Valakunja Nagaraja, Nucleic Acids Res., 2013, 41, 7462-7471

• Prof. Reinhard Lührmann, Dept. of Cellular Biochemistry, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany, 37077, Reinhard.Luehrmann@mpi-bpc.mpg.de, +49 551 2011405
• Prof. Valakunja Nagaraja, Dept. of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bangalore, Karnataka, 560012, vraj@iisc.ac.in, +91 80 22932598
• Prof. Ajith Kumar, Dept. of Microbiology and Cell Biology, Indian Institute of Science (IISc), Bangalore, Karnataka, 560012, ajit@iisc.ac.in, +91 80 22932344
• Prof. Henning Urlaub, Mass spectrometry division, Dept. of Cellular Biochemistry, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany, 37077, henning.urlaub@mpibpc.mpg.de, +49 551 2011470

• Place of Birth: Vijayawada, India
• Date of Birth: 02/21/1980
• Nationality: Indian
• Work permit : B

• Music and movies
• Badminton