Tianyu Chen
Nanjing
Overview
14
14
years of professional experience
1
1
Certification
Work History
Anesthesiology Resident
Children's Hospital of Fudan University
08.2022 - 08.2023
- Operated numerous pediatric anaesthesia operations, including common diseases such as indirect hernia and appendicitis, as well as complex conditions such as diaphragmatic hernia, biliary atresia and traumatic shock
- Experienced in anaesthesia techniques, including laparoscopic surgery, cardiovascular interventional therapy, CT and MRI
- Adjusted the dosage of anaesthesia according to the weight of the child to ensure their well-being
- EXPERIMENTAL ABILITIES
- Clinical Trial
- Experienced in writing clinical ethics, collecting whole blood from adults and children, and conducting human blood cell centrifugation and white blood cell extraction
- Animal Testing
- Capable of establishing long-term inhalational anaesthesia model and constructing physical restraint mouse models, water maze experiments, and mouse diabetes research models; Experienced in extracting mouse's cerebral cortex and hippocampal tissue and performing brain tissue slices
- Cell Experiments
- Trained in primary neuronal cell isolation, neuronal cell cryopreservation, recovery, culture, drug intervention and harvest
- Biochemical Test
- Western Blot (WB); Real-Time Quantitative Reverse Transcription PCR (qRT-PCR); Flow Cytometry.
Anesthesiology Resident
The First Affiliated Hospital of Zhejiang University School of Medicine
07.2021 - 12.2022
- Focused on orthopaedic and thoracic surgeries and gained sophisticated experience in local and general anaesthesia in operations, such as bone fracture repair, joint replacement and spinal surgeries
- Involved in emergency operations caused by severe arrest, infection, trauma or cerebral haemorrhage
- Performed anaesthesia and analgesia management during operation and provided invasive operations and advanced life support.
Program
National Natural Science Foundation of China
01.2018 - 12.2022
- The Role and Mechanism of SCOP-mediated "Sleep-Wake" Rhythm Disorder in POCD of Elderly Patients
- National Science Fund for Distinguished Young Scholars
01.2018 - 12.2020
- The Mechanism of RbAp48 in glucocorticoid-mediated POCD in Elderly Patients, Research on the Influence of Isoflurane Anesthesia on the Transcription of RORα and Rev-erbα Genes in the the Hippocampus and Cerebral Cortex of Mice
- Researcher
- Research Outcomes, China, 2021
- Neuronal damage induced by isoflurane was identified in the hippocampus, affecting mice's episodic memories
- The RORα mRNA expression of the test subject was upregulated in the cerebral cortex while downregulated in the hippocampus
- Significant decreased Rev-erbα mRNA expression was identified in the cerebral cortex
- The RORα and Rev-erbα mRNA expressions in the hippocampus and cerebral cortex of normal mice remained in a 24-hour per cycle circadian rhythm
- However, the mice with anaesthesia administration demonstrated a phase shift in circadian rhythm.
Standardized Resident
Zhongda Hospital of Southeast University
07.2015 - 07.2018
- Received standard training in level A tertiary hospital, attended over 50 residency sessions, and studied clinical cases and ward round procedures
- Accomplished numerous surgical anaesthesia and pain management and independently performed general anaesthesia and neuraxial anaesthesia
- Assisted in the operation of EF26% laparoscopic cholecystectomy in general anaesthesia
- Engaged in the perioperative management of critically ill patients, and executed multiple acute pain management or ICU management.
09.2009 - 06.2014
Medical Intern
Nanjing Drum Tower Hospital
01.2013 - 01.2014
- Practised various anaesthesia operations, including tracheal intubation, vein puncture and artery puncture, as well as basic operations in treating anaesthetized patients
- Trained in operating ventilator and ECG monitor and analysing the indexes
- Acquired knowledge of the diagnosis and treatment of emergency patients
- Performed respiratory support treatment of critically ill patients.
Education
Master of Medicine - Clinical Medicine
Nanjing University
Postgraduate - undefined
Bachelor of Medicine - undefined
Wannan Medical College, Wannan
Skills
- SKILLS & CERTIFICATION
- Computer Language: R
- Computer Software:
- Photoshop, GraphPad Prism
Accomplishments
- Isoflurane anaesthesia can influence the transcription of RORα and Rev-erbα genes in the hippocampus and cerebral cortex of mice and induce phase shifts in circadian rhythm
- The Effects of Melatonin on TRF1 Protein in Human Neuroblastoma Cells Treated with Isoflurane
- Researcher
- Research Outcomes:
- Melatonin can induce anti-neurotoxic response by up-regulating the phosphorylation level of Akt (Ser473)
- Nanjing, China, 2022
- The protein levels of p-Akt (Ser473) and TRF1 in SH-SY5Y cells were significantly increased in the treatment with 100 nmol/L concentration of melatonin and 1.5% isoflurane
- The results showed BYL719 inhibit the increase of p-Akt and TRF1 caused by melatonin in SH-SY5Y cells, suggesting melatonin can increase the TRF1 in SH-SY5Y cells through the PI3K/Akt pathway
- Summary:
- Melatonin can drastically increase TRF1 protein in human neuroblastoma cells, which is related to the PI3K/Akt pathway
- A Study of Changes in TRF1 Protein Expression and Apoptosis of Blood Cell in Pediatric Anesthesia
- Researcher
- The research suggested new research areas and related mechanisms for recovery from inhalational anaesthetic-induced cell damage
- A Study of the Relationshipo between Human Physiological Parameters and Face Recognition Information (Clinical Trials)
- Researcher
- Nanjing, China, 2019-2020
- Recruited and recorded information on 5,000 physical examination candidates for the clinical trial
- Compared and studied the physical examination data and test results of TOI software
- Investigated and assessed the physical indexes of the candidates with different heart rate variability
- Examined the difference in heart rate variability in candidates of different genders.
Certification
Good Clinical Practice Certificate, Medical Practitioners Certificate of the People's Republic of China, Practicing Doctors Qualification of the People's Republic of China, Attending Doctor Certification.
Languages
English
Timeline
Anesthesiology Resident
Children's Hospital of Fudan University
08.2022 - 08.2023
Anesthesiology Resident
The First Affiliated Hospital of Zhejiang University School of Medicine
07.2021 - 12.2022
Program
National Natural Science Foundation of China
01.2018 - 12.2022
01.2018 - 12.2020
Standardized Resident
Zhongda Hospital of Southeast University
07.2015 - 07.2018
Medical Intern
Nanjing Drum Tower Hospital
01.2013 - 01.2014
09.2009 - 06.2014
Master of Medicine - Clinical Medicine
Nanjing University
Postgraduate - undefined
Bachelor of Medicine - undefined
Wannan Medical College, Wannan
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