KNIME
Zsolt Bognar
PhD Graduate In Chemistry
Morges
Summary
PhD student in Chemistry with MSc in Pharmaceutical Engineering, with experience in solid-phase and solution phase peptide synthesis, high-throughput experimentation and screening, analytical methods (LC-MS, NMR), preparative organic and medicinal chemistry, chromatographic purification techniques, and computational chemistry.
Overview
8
8
years of professional experience
11
11
years of post-secondary education
4
4
Languages
Work History
Doctoral assistant
Swiss Federal Institute of Technology-Lausanne (EPFL)
03.2020 - 04.2024
- Developed novel and robust methods for automated synthesis (CEM Multipep SPPS platform), analysis (LC-MS) and late-stage nanoscale diversification of combinatorial peptide libraries, with more than 20,000 distinct compounds
- Co-inventor in patent covering these technologies, which are now routinely used by spin-off company
- Established biochemical assays (TR-FRET, FP, kinetic)
- Identified novel biologically active compounds by high-throughput screening, routinely using automated liquid handling (Access Workstation, ECHO acoustic liquid handling, Certus Flex).
- Mentored Master students to achieve impactful scientific results
Medicinal Chemistry Intern
F. Hoffmann - La Roche AG
09.2018 - 09.2019
- Planned and independently performed multi-step synthesis and chromatographic purification of several small molecules and PROTACs
- Monitored reaction progression and characterized products by LC-MS and NMR
- Recorded all experimental data in ELN system with perfect precision, enabling easy replication for others
- Analyzed activity (SAR) and ADMET data from biological assays, and participated in structural optimization of lead compounds for an oncology-related project.
Student researcher
Hungarian Academy of Sciences
07.2017 - 01.2020
- Identified novel inhibitors of an enzyme involved in haematologic malignancies (SETD2) by designing and conducting Virtual Screening campaign with more than 5 million compounds (Schrödinger, KNIME)
Intern
Gedeon Richter Plc.
07.2016 - 08.2016
- Performed organic synthesis reactions for process development and scale-up
Education
Ph.D. - Chemistry
Swiss Federal Institute of Technology (EPFL)
Lausanne, Switzerland 04.2020 - 05.2024
Master of Science - Pharmaceutical Engineering
Budapest University of Technology And Economics
Budapest, Hungary 04.2017 - 04.2020
Bachelor of Science - Chemical Engineering
Budapest University of Technology And Economics
Budapest, Hungary 04.2013 - 04.2017
Skills
Organic synthesis
undefinedPersonal Information
- Date of Birth: 06/18/94
- Nationality: Hungarian
Publications
Org. Biomol. Chem. 2022, 20, 5699-5703,
Int. J. Mol. Sci. 2021, 22(18), 10055,
Nat. Comm. 2022, 13, 3823,
WO2022242993 (A1)
Software
MS Office
Schrödinger
DataWarrior
GraphPad Prism
Adobe Illustrator
Timeline
Ph.D. - Chemistry
Swiss Federal Institute of Technology (EPFL)
04.2020 - 05.2024
Doctoral assistant
Swiss Federal Institute of Technology-Lausanne (EPFL)
03.2020 - 04.2024
Medicinal Chemistry Intern
F. Hoffmann - La Roche AG
09.2018 - 09.2019
Student researcher
Hungarian Academy of Sciences
07.2017 - 01.2020
Master of Science - Pharmaceutical Engineering
Budapest University of Technology And Economics
04.2017 - 04.2020
Intern
Gedeon Richter Plc.
07.2016 - 08.2016
Bachelor of Science - Chemical Engineering
Budapest University of Technology And Economics
04.2013 - 04.2017
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