Summary
Overview
Work History
Education
Skills
References
Refereed Publications
Skills
Personal Information
Languages
Timeline
Generic
Sonja Kroschwald

Sonja Kroschwald

Urdorf

Summary

Passionate candidate with strong experience in condensate and amyloid biology, as well as solid understanding of related disorders. Self-motivated, organized and dependable to manage efficiently multiple priorities simultaneously with a positive attitude. Hardworking and committed across function. Willing to take on added responsibilities to support and guide the team towards the corporate goal.

Overview

17
17
years of professional experience

Work History

Postdoctoral Research Scientist

ETH, Institut Of Biochemistry
2017.05 - Current
  • Topics: Discovering the regulatory mechanisms of stress granule amyloid formation in S.cerevisiae (Head: Prof. Dr. Matthias Peter)
  • Techniques: Advanced Mass Spectrometry, Metabolomics, live-cell imaging/ analysis, purification strategies, AFM, negative stain TEM
  • Research conception, design and execution to address defined problems.
  • Built and maintained professional relationships with students, team members and faculty members.

Wrapping-Up Postdoctoral Research Scientist

MPI-CBG
2014.10 - 2017.04
  • Topics: Identified hexanediol, as a compound to prevent FUS amyloid formation/ Studied condensate formation during distinct modes of cellular stress adaptation in S.cerevisiae (Head: Prof. Dr. Simon Alberti/ Prof. Dr. Anthony Hyman)
  • Techniques: Purifications strategies from sf9 cells, phase diagrams, quantitative image analysis
  • Published research results in peer-reviewed journals and presented at seminars and meetings.

Graduate Student Researcher

MPI-CBG
2010.10 - 2014.09
  • Topics: Elucidated the formation mechanisms of P bodies and stress granules in S.cerevisiae (Head: Prof. Dr. Simon Alberti)
  • Techniques: advanced biochemical methods (SDD-AGE), genetic engineering, high resolution live-cell imaging and quantitative image analysis
  • Interpreted and analyzed research data to draw conclusions on outcomes.

Student Research Assistant

MPI-CBG
2010.04 - 2010.09
  • Topics: Research on actin cortex mechanics and cell shape (Head: Prof. Dr. Ewa Paluch)
  • Techniques: mammalian cell culture and live-cell imaging with laser ablation

Intern

Wellcome Trust/Cancer Research UK Gurdon Institute
2009.10 - 2010.03
  • Topics: Studied cell polarity in C.elegans (Head: Dr. Julie Ahringer)
  • Acquired know-how about C.elegans biology, conducted RNAi screens and confocal microscopy

Master Student

MPI-CBG
2009.02 - 2009.09
  • Topics: Studied actin cortex mechanics and cell shape (Head: Prof. Dr. Ewa Paluch)
  • Techniques: mammalian cell cultures (Hela Kyoto), live cell imaging with laser ablation and image analysis

Undergraduate Student

Medical Theoretical Center
2007.02 - 2007.08
  • Topics: Analyzed proliferation and differentiation of mouse cell line 3T3 L1 (Head: Dr. Monika Ehrhardt-Bornstein)
  • Techniques: gained experience with mouse cell line 3T3 L1, quantitative PCR

Intern

Technical University
2006.07 - 2006.10
  • Topics: Characterization of pyrrolnitrin biosynthetic enzyme by HPLC (Head: Prof. Dr. Karl-Heinz van Pée)

Education

Ph.D. - Molecular Biology

Max Planck Institute of Molecular Cell Biology And Genetics
Dresden, Germany
04.2015

Master of Science - Cellular And Molecular Biology

Biotechnology Center - Technical University Dresden
Dresden, Germany
09.2009

Bachelor of Science - Bioengineering

University of Applied Sciences Zittau/Görlitz
Dresden, Germany
08.2007

Skills

  • Research experience in vitro and in vivo
  • Development of amyloid targeting compounds
  • Project Management and Leadership
  • Data Science
  • Interdisciplinary Coordination

References

  • Prof. Dr. Matthias Peter, ETH Zürich, Zürich, Schweiz, matthias.peter@bc.biol.ethz.ch
  • Prof. Dr. Simon Alberti, BIOTEC/ TU Dresden, Dresden, Deutschland, simon.alberti@tu-dresden.de
  • Prof. Ewa Paluch, MRC LMCB, University College London, UK, e.paluch@ucl.ac.uk

Refereed Publications

  • 2022, Editorial: Molecular determinants of protein assemblies in health and disease, Kroschwald, S., Arunagiri, A., Ventura, S., Ranganathan, S., Kohler, V., Front. Mol. Biosci., 9
  • 2018, Different material states of Pub1 condensates define distinct modes of stress adaptation and recovery, Kroschwald, S., Munder, M.C., Richter, D., Hyman, A.A., Alberti, S., Cell Reports, 23(11), 3327-3339
  • 2017, Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments, Kroschwald, S., Maharana, S., Alberti, S., Science Matters
  • 2017, Gel or Die: Phase Separation as Survival Strategy, Kroschwald, S., Alberti, S., Cell, 168(6), 947-948
  • 2015, Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules, Kroschwald, S., Maharana, S., Mateju, D., Malinovska, L., Nüske, E., Poser, I., Richter, D., Alberti, S., eLIFE, 4, e06807
  • 2014, Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation, Petrovska,I., Nüske,E., Munder,M.C., Kulasegaran,G., Malinovska,L., Kroschwald,S., Richter,D., Fahmy,K., Gibson,K., Verbavatz,J.-M., Alberti,S., eLife, 3, e02409
  • 2013, Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging, Biro,M., Romeo,Y., Kroschwald,S., Bovellan,M., Boden,A., Tcherkezian,J., Roux,P.P., Charras,G., Paluch,E., Cytoskeleton, 70(11), 741-754
  • 2012, Protein disorder, prion propensities, and self-organizing macromolecular collectives, Malinovska,L., Kroschwald,S., Alberti,S., BIOCHIM BIOPHYS ACTA., 1834(5), 918-931
  • 2012, Molecular chaperones and stress-inducible protein sorting factors coordinate the spatio-temporal distribution of protein aggregates, Malinovska,L., Kroschwald,S., Munder,M., Richter,D., Alberti,S., Mol. Biol. Cell, 23:16, 3041-3056
  • 2006, Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway, De Laurentis,W., Leang,K., Hahn,K., Podemski,B., Adam,A., Kroschwald,S., Carter,L. G., van Pee,K. H., Naismith,J. H., Acta Crystallogr Sect F Struct Biol Cryst Commun, 62, 1134-1137

Skills

R, ImageJ/Fiji, Imaris, CellProfiler, Keynote, PowerPoint, Photoshop, Illustrator, Papers, Endnote

Personal Information

  • Number of Children: 2
  • Date of Birth: 05/08/84

Languages

German
Bilingual or Proficient (C2)
English
Bilingual or Proficient (C2)
French
Beginner (A1)

Timeline

Postdoctoral Research Scientist

ETH, Institut Of Biochemistry
2017.05 - Current

Wrapping-Up Postdoctoral Research Scientist

MPI-CBG
2014.10 - 2017.04

Graduate Student Researcher

MPI-CBG
2010.10 - 2014.09

Student Research Assistant

MPI-CBG
2010.04 - 2010.09

Intern

Wellcome Trust/Cancer Research UK Gurdon Institute
2009.10 - 2010.03

Master Student

MPI-CBG
2009.02 - 2009.09

Undergraduate Student

Medical Theoretical Center
2007.02 - 2007.08

Intern

Technical University
2006.07 - 2006.10

Ph.D. - Molecular Biology

Max Planck Institute of Molecular Cell Biology And Genetics

Master of Science - Cellular And Molecular Biology

Biotechnology Center - Technical University Dresden

Bachelor of Science - Bioengineering

University of Applied Sciences Zittau/Görlitz
Sonja Kroschwald